{"id":540,"date":"2025-10-09T07:25:08","date_gmt":"2025-10-09T07:25:08","guid":{"rendered":"https:\/\/dermatide.net\/?page_id=540"},"modified":"2026-10-25T02:54:20","modified_gmt":"2026-10-25T02:54:20","slug":"%ea%b3%bc%ed%95%99%ec%a0%81-%ec%a6%9d%ea%b1%b0","status":"publish","type":"page","link":"https:\/\/dermatide.net\/ko\/science-evidence\/","title":{"rendered":"\uacfc\ud559 \ubc0f \uc99d\uac70"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"540\" class=\"elementor elementor-540\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d978988 e-flex e-con-boxed e-con e-child\" data-id=\"d978988\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-da8de9c e-flex e-con-boxed e-con e-child\" data-id=\"da8de9c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3b7f8bd elementor-widget elementor-widget-heading\" data-id=\"3b7f8bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Tracing the <span class=\"custom-text-color\">Scientific Breakthroughs Behind<\/span> AKNETIDE<sup>\u00ae<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b00e125 elementor-widget elementor-widget-text-editor\" data-id=\"b00e125\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>AKNETIDE<sup>\u00ae <\/sup>R&amp;D has been grounded over a decade of research from molecular discovery to clinical validation. Below is a snapshot of key scientific and regulatory milestones that demonstrate its journey from lab bench to real-world acne care efficacy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8145415 e-grid e-con-full e-con e-child\" data-id=\"8145415\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-bcd4502 e-con-full e-flex e-con e-child\" data-id=\"bcd4502\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5d54a0c eael-infobox-content-align--left eael-infobox-icon-bg-shape-none eael-infobox-icon-hover-bg-shape-none elementor-widget elementor-widget-eael-info-box\" data-id=\"5d54a0c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-info-box.default\">\n\t\t\t\t\t        <div class=\"eael-infobox icon-on-top\">\n\t            <div class=\"infobox-icon\">\n\n            \n            \n                            <div class=\"infobox-icon-wrap\">\n                    <span class=\"infobox-icon-number\"><\/span>\n                <\/div>\n            \n        <\/div>\n            <div class=\"infobox-content\">\n                    <div class=\"infobox-title-section\">\n                <h4 class=\"sub_title\">2014<\/h4><h2 class=\"title\">Inception of AMP<\/h2>            <\/div>\n            <div><p>Inception of antimicrobial peptide discovery from nature and lab development<\/p><\/div>        <\/div>\n            <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f4a45f e-con-full e-flex e-con e-child\" data-id=\"7f4a45f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1ee4377 eael-infobox-content-align--left eael-infobox-icon-bg-shape-none eael-infobox-icon-hover-bg-shape-none elementor-widget elementor-widget-eael-info-box\" data-id=\"1ee4377\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-info-box.default\">\n\t\t\t\t\t        <div class=\"eael-infobox icon-on-top\">\n\t            <div class=\"infobox-icon eael-icon-only\">\n\n            \n                            <div class=\"infobox-icon-wrap\">\n                    <svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8z\"><\/path><\/svg>                <\/div>\n            \n            \n        <\/div>\n            <div class=\"infobox-content eael-icon-only\">\n                    <div class=\"infobox-title-section\">\n                <h4 class=\"sub_title\">2023<\/h4><h2 class=\"title\">The cyclopeptide was discovered<\/h2>            <\/div>\n            <div><p>AKNETIDE<sup>\u00ae<\/sup>, a novel antimicrobial cyclopeptide\u00a0with potent inhibition against <em>C. acne<\/em> and <em>S. aureus<\/em>,\u00a0was discovered<\/p><\/div>        <\/div>\n            <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ef517d eael-infobox-content-align--left eael-infobox-icon-bg-shape-none eael-infobox-icon-hover-bg-shape-none elementor-widget elementor-widget-eael-info-box\" data-id=\"8ef517d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-info-box.default\">\n\t\t\t\t\t        <div class=\"eael-infobox icon-on-top\">\n\t            <div class=\"infobox-icon eael-icon-only\">\n\n            \n                            <div class=\"infobox-icon-wrap\">\n                    <svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8z\"><\/path><\/svg>                <\/div>\n            \n            \n        <\/div>\n            <div class=\"infobox-content eael-icon-only\">\n                    <div class=\"infobox-title-section\">\n                <h4 class=\"sub_title\">2024<\/h4><h2 class=\"title\">First clinical study by SGS<\/h2>            <\/div>\n            <div><p>The first-ever clinical study, with SGS Cosmetic Lab, was completed and demonstrated the significant efficacy of sensible acne level alleviation<\/p><\/div>        <\/div>\n            <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-110dcf0 e-con-full e-flex e-con e-child\" data-id=\"110dcf0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d3a15e eael-infobox-content-align--left eael-infobox-icon-bg-shape-none eael-infobox-icon-hover-bg-shape-none elementor-widget elementor-widget-eael-info-box\" data-id=\"6d3a15e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-info-box.default\">\n\t\t\t\t\t        <div class=\"eael-infobox icon-on-top\">\n\t            <div class=\"infobox-icon eael-icon-only\">\n\n            \n                            <div class=\"infobox-icon-wrap\">\n                    <svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8z\"><\/path><\/svg>                <\/div>\n            \n            \n        <\/div>\n            <div class=\"infobox-content eael-icon-only\">\n                    <div class=\"infobox-title-section\">\n                <h4 class=\"sub_title\">2025<\/h4><h2 class=\"title\">Multi-MOAs established<\/h2>            <\/div>\n            <div><p><strong><b>Mechanism Elucidation<\/b><\/strong><strong><b>: <\/b><\/strong>Multi-MOAs were established and proven by a leading cosmetic research institute<\/p><\/div>        <\/div>\n            <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-pa-eq-height=\"{&quot;targetType&quot;:&quot;widget&quot;,&quot;target&quot;:[],&quot;trigger&quot;:&quot;load&quot;,&quot;enableOn&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\" class=\"elementor-element elementor-element-d72f966 premium-equal-height-yes e-flex e-con-boxed e-con e-parent\" data-id=\"d72f966\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;premium_eq_height_switcher&quot;:&quot;yes&quot;,&quot;premium_eq_height_target&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e83d1ee elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"e83d1ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Clinically proven and Dermatologist Tested evidence behind <span class=\"custom-text-color\"> AKNETIDE<sup>\u00ae <\/sup><\/span> <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f9ff55 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"7f9ff55\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Backed by 10+ years of rigorous consistent research of antimicrobial bioactive peptides, and recently validated by leading independent biochemical laboratories, AKNETIDE\u00ae\u00a0harvested myriads of evidences, either of mechanism or of clinical studies, enables it deserving\u00a0a\u00a0worldwide breakthrough anti acne cosmetic ingredient designed for EFFICACY\u00a0without bragging.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-291d71f e-con-full e-flex e-con e-child\" data-id=\"291d71f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-07e79f5 e-con-full premium-wrapper-link-yes e-flex e-con e-child\" data-id=\"07e79f5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ddc4d27 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"ddc4d27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Double-blind, placebo-controlled, split-face clinical study with Intertek<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-95fb009 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"95fb009\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>A 34-subject, double-blind, placebo-controlled, split-face clinical study of AKNETIDE<sup>\u00ae<\/sup> with Intertek (each subject used AKNETIDE<sup>\u00ae<\/sup> on one half of the face and placebo on the other) was completed in early 2026; the study report is to be published.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6aa20a4 elementor-align-left elementor-widget elementor-widget-button\" data-id=\"6aa20a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjEyMzciLCJ0b2dnbGUiOnRydWV9\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">View Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-15868c6 e-con-full e-flex e-con e-child\" data-id=\"15868c6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6cf024a elementor-widget elementor-widget-heading\" data-id=\"6cf024a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">SGS Clinical Study<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0430d5d elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"0430d5d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>AKNETIDE<sup>\u00ae <\/sup>embedded prototype formula demonstrated potent efficacy in significantly alleviating volunteers&#8217; acne conditions from black heads to papules in 7 days.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f482dfc elementor-align-left elementor-widget elementor-widget-button\" data-id=\"f482dfc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjEyNDUiLCJ0b2dnbGUiOnRydWV9\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">View Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b5e4c9a e-con-full e-flex e-con e-child\" data-id=\"b5e4c9a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-534daf0 elementor-widget elementor-widget-heading\" data-id=\"534daf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">In-vitro Safety Studies<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2bc18b9 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"2bc18b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Skin irritation, phototoxicity, eye irritation, sensitization\u00a0to skin were all tested NEGATIVE; \u00a0HaCaT MTT Toxicity data was given.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b21a399 elementor-align-left elementor-widget elementor-widget-button\" data-id=\"b21a399\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjE0ODAiLCJ0b2dnbGUiOnRydWV9\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">View Study<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e7f759d e-flex e-con-boxed e-con e-parent\" data-id=\"e7f759d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f5bd552 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"f5bd552\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-30fed45 e-flex e-con-boxed e-con e-parent\" data-id=\"30fed45\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-06944e7 elementor-widget elementor-widget-heading\" data-id=\"06944e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Published Studies and Patents<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1e6ea0e e-flex e-con-boxed e-con e-parent\" data-id=\"1e6ea0e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c28bd6f elementor-widget elementor-widget-text-editor\" data-id=\"c28bd6f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Peer-reviewed in-vitro mechanism paper<\/strong><\/p><p>Yu N, Guo G, Zhang L, He T, Zhang M, Wang J, Wang J, Yao R, Wang G-L, Wang J. <em>An antimicrobial cyclic peptide with multitarget efficacy for acne.<\/em> <em>Scientific Reports<\/em> (Nature Portfolio), published 11 October 2026. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41598-026-75285-7\">https:\/\/doi.org\/10.1038\/s41598-026-75285-7<\/a><\/p><p>In the paper, the peptide is referred to as AMCP (antimicrobial cyclic peptide); it is the peptide contained in AKNETIDE\u00ae.<\/p><p>News coverage (in Chinese): <a href=\"https:\/\/mp.weixin.qq.com\/s\/3GrrrfxMrQKj1CAjxUP53g\" target=\"_blank\" rel=\"noopener\">Jiangnan University&#8217;s article on the paper<\/a>, from the research institution behind the study.<\/p><p>This is a laboratory (in-vitro) mechanism study, separate from the clinical studies.<\/p><p>The 34-subject, double-blind, placebo-controlled, split-face clinical study conducted by Intertek is to be published.<\/p><p>Co-authored by Robin Yao of Dermatide Biotec Pte Ltd. (Singapore).<\/p><p><strong>In plain language:<\/strong> In laboratory (in-vitro) studies, the antimicrobial cyclic peptide behind AKNETIDE<sup>\u00ae<\/sup> killed <em>C. acnes<\/em> and <em>S. aureus<\/em> at low concentrations, reduced hormone- and fatty-acid-induced lipid production in human sebocytes, and lowered key inflammatory mediators in skin cells. It also supported keratinocyte migration and skin-barrier differentiation markers, pointing to a multi-target mechanism covering sebum control, antibacterial action, anti-inflammation and repair.<\/p><p><a href=\"https:\/\/www.nature.com\/articles\/s41598-026-75285-7\" target=\"_blank\" rel=\"noopener\">Read the open-access paper in Scientific Reports<\/a><\/p><p><strong>Patents pending.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b011bcc elementor-widget elementor-widget-html\" data-id=\"b011bcc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"ScholarlyArticle\", \"name\": \"An antimicrobial cyclic peptide with multitarget efficacy for acne\", \"headline\": \"An antimicrobial cyclic peptide with multitarget efficacy for acne\", \"author\": [{\"@type\": \"Person\", \"name\": \"Yu N\"}, {\"@type\": \"Person\", \"name\": \"Guo G\"}, {\"@type\": \"Person\", \"name\": \"Zhang L\"}, {\"@type\": \"Person\", \"name\": \"He T\"}, {\"@type\": \"Person\", \"name\": \"Zhang M\"}, {\"@type\": \"Person\", \"name\": \"Wang J\"}, {\"@type\": \"Person\", \"name\": \"Wang J\"}, {\"@type\": \"Person\", \"name\": \"Robin Yao\", \"affiliation\": {\"@type\": \"Organization\", \"name\": \"Dermatide Biotec Pte Ltd\"}}, {\"@type\": \"Person\", \"name\": \"Wang G-L\"}, {\"@type\": \"Person\", \"name\": \"Wang J\"}], \"isPartOf\": {\"@type\": \"Periodical\", \"name\": \"Scientific Reports\", \"publisher\": {\"@type\": \"Organization\", \"name\": \"Nature Portfolio\"}}, \"datePublished\": \"2026-10-11\", \"identifier\": {\"@type\": \"PropertyValue\", \"propertyID\": \"DOI\", \"value\": \"10.1038\/s41598-026-75285-7\"}, \"sameAs\": \"https:\/\/doi.org\/10.1038\/s41598-026-75285-7\", \"url\": \"https:\/\/www.nature.com\/articles\/s41598-026-75285-7\", \"about\": \"In-vitro mechanism study of AKNETIDE (antimicrobial cyclopeptide)\", \"subjectOf\": {\"@type\": \"NewsArticle\", \"url\": \"https:\/\/mp.weixin.qq.com\/s\/3GrrrfxMrQKj1CAjxUP53g\", \"inLanguage\": \"zh\", \"headline\": \"Jiangnan University's article on the paper\", \"publisher\": {\"@type\": \"CollegeOrUniversity\", \"name\": \"Jiangnan University\"}}}<\/script>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f9cd32f e-flex e-con-boxed e-con e-parent\" data-id=\"f9cd32f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-171b7dd elementor-widget elementor-widget-text-editor\" data-id=\"171b7dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<section class=\"faq\"><h2>Questions and answers<\/h2>\n  <h3>What is AKNETIDE\u00ae?<\/h3>\n  <p>A fermentation-derived cosmetic ingredient, supplied as a filtrate, for blemish-prone and acne-prone skin care. It&#8217;s COSMOS approved, Halal certified and Dermatologist Tested.<\/p>\n  <p>Source: Dermatide Biotec Pte Ltd.<\/p>\n\n  <h3>Is AMCP the same as AKNETIDE\u00ae?<\/h3>\n  <p>AMCP, i.e. AntiMicrobial CycloPeptide, is the paper&#8217;s name for the specified bio-active peptide contained in AKNETIDE\u00ae. AKNETIDE\u00ae itself is the commercial product with INCI: Bacillus Ferment, not the peptide alone. The ring structure of the AMCP within AKNETIDE\u00ae was supported by scientific evidence.<\/p>\n  <p>Source: Yu et al., Scientific Reports, 11 Oct 2026, DOI 10.1038\/s41598-026-75285-7.<\/p>\n\n  <h3>What does the paper show, and not show?<\/h3>\n  <p>In laboratory tests, AMCP showed activity against C. acnes and S. aureus, reduced lipid synthesis in SZ95 sebocytes, reduced inflammatory mediators (IL-6, IL-8, IL-1\u03b2, TNF-\u03b1, PGE2) in HaCaT keratinocytes and SZ95 sebocytes, promoted keratinocyte migration and modulated epidermal differentiation genes.<\/p>\n  <p>Limit: the evidence is laboratory (in vitro \/ ex vivo), not on human skin. Source: Yu et al., Scientific Reports, 11 Oct 2026, DOI 10.1038\/s41598-026-75285-7.<\/p>\n\n  <h3>Is AKNETIDE\u00ae a purified peptide?<\/h3>\n  <p>No. AKNETIDE\u00ae is a fermentation-derived filtrate, not an isolated or purified peptide.<\/p>\n  <p>Limit: the purity figure in the paper refers to the peptide sample studied, not to AKNETIDE\u00ae.<\/p>\n\n  <h3>Which evidence is laboratory and which is human?<\/h3>\n  <p>The paper\u2019s findings are laboratory (in vitro \/ ex vivo) results. Human evidence comes from an open-label SGS clinical study and a double-blind, placebo-controlled, split-face clinical study conducted by Intertek.<\/p>\n  <p>Limit: the paper does not include human-skin data. Source: Yu et al., Scientific Reports, 11 Oct 2026, DOI 10.1038\/s41598-026-75285-7.<\/p>\n\n  <h3>What is the use level?<\/h3>\n  <p>The use level is 0.25%~2.0%, typically 1%.<\/p>\n  <p>Source: Dermatide Biotec Pte Ltd.<\/p>\n\n  <h3>Is there a clinical study?<\/h3>\n  <p>Yes. An open-label SGS study ran for 28 days with measurements at baseline and at scheduled visits during the study, and a 34-subject, double-blind, placebo-controlled, split-face study was conducted by Intertek.<\/p>\n  <p>Limit: the Intertek study is to be published (no journal or DOI yet).<\/p>\n\n  <h3>How do I start an evaluation?<\/h3>\n  <p>Email info@dermatide.net or use the Collaboration Exploration page (\/en-us\/collaboration-exploration\/). The technical dataset is shared under NDA.<\/p>\n  <p>Source: Dermatide Biotec Pte Ltd.<\/p>\n<\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f9cf922 elementor-widget elementor-widget-html\" data-id=\"f9cf922\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"What is AKNETIDE\u00ae?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"A fermentation-derived cosmetic ingredient, supplied as a filtrate, for blemish-prone and acne-prone skin care. It's COSMOS approved, Halal certified and Dermatologist Tested. Source: Dermatide Biotec Pte Ltd.\"}}, {\"@type\": \"Question\", \"name\": \"Is AMCP the same as AKNETIDE\u00ae?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"AMCP, i.e. AntiMicrobial CycloPeptide, is the paper's name for the specified bio-active peptide contained in AKNETIDE\u00ae. AKNETIDE\u00ae itself is the commercial product with INCI: Bacillus Ferment, not the peptide alone. The ring structure of the AMCP within AKNETIDE\u00ae was supported by scientific evidence. Source: Yu et al., Scientific Reports, 11 Oct 2026, DOI 10.1038\/s41598-026-75285-7.\"}}, {\"@type\": \"Question\", \"name\": \"What does the paper show, and not show?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"In laboratory tests, AMCP showed activity against C. acnes and S. aureus, reduced lipid synthesis in SZ95 sebocytes, reduced inflammatory mediators (IL-6, IL-8, IL-1\u03b2, TNF-\u03b1, PGE2) in HaCaT keratinocytes and SZ95 sebocytes, promoted keratinocyte migration and modulated epidermal differentiation genes. Limit: the evidence is laboratory (in vitro \/ ex vivo), not on human skin. Source: Yu et al., Scientific Reports, 11 Oct 2026, DOI 10.1038\/s41598-026-75285-7.\"}}, {\"@type\": \"Question\", \"name\": \"Is AKNETIDE\u00ae a purified peptide?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"No. AKNETIDE\u00ae is a fermentation-derived filtrate, not an isolated or purified peptide. Limit: the purity figure in the paper refers to the peptide sample studied, not to AKNETIDE\u00ae.\"}}, {\"@type\": \"Question\", \"name\": \"Which evidence is laboratory and which is human?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"The paper\u2019s findings are laboratory (in vitro \/ ex vivo) results. Human evidence comes from an open-label SGS clinical study and a double-blind, placebo-controlled, split-face clinical study conducted by Intertek. Limit: the paper does not include human-skin data. Source: Yu et al., Scientific Reports, 11 Oct 2026, DOI 10.1038\/s41598-026-75285-7.\"}}, {\"@type\": \"Question\", \"name\": \"What is the use level?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"The use level is 0.25%~2.0%, typically 1%. Source: Dermatide Biotec Pte Ltd.\"}}, {\"@type\": \"Question\", \"name\": \"Is there a clinical study?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes. An open-label SGS study ran for 28 days with measurements at baseline and at scheduled visits during the study, and a 34-subject, double-blind, placebo-controlled, split-face study was conducted by Intertek. Limit: the Intertek study is to be published (no journal or DOI yet).\"}}, {\"@type\": \"Question\", \"name\": \"How do I start an evaluation?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Email info@dermatide.net or use the Collaboration Exploration page (\/en-us\/collaboration-exploration\/). The technical dataset is shared under NDA. Source: Dermatide Biotec Pte Ltd.\"}}]}<\/script>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3514eac e-flex e-con-boxed e-con e-parent\" data-id=\"3514eac\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3678c2a elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3678c2a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Tracing the Scientific Breakthroughs Behind AKNETIDE\u00ae AKNETIDE\u00ae R&amp;D has been grounded over a decade of research from molecular discovery to clinical validation. Below is a snapshot of key scientific and regulatory milestones that demonstrate its journey from lab bench to real-world acne care efficacy. 2014 Inception of AMP Inception of antimicrobial peptide discovery from nature [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-540","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Science &amp; Evidence - Dermatide<\/title>\n<meta name=\"description\" content=\"The science behind AKNETIDE\u00ae: in-vitro mechanism paper in Scientific Reports (2026), an open-label SGS clinical study and a 34-subject, double-blind, placebo-controlled, split-face clinical study conducted by Intertek (to be published).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dermatide.net\/ko\/\uacfc\ud559\uc801-\uc99d\uac70\/\" \/>\n<meta property=\"og:locale\" content=\"ko_KR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science &amp; Evidence - Dermatide\" \/>\n<meta property=\"og:description\" content=\"The science behind AKNETIDE\u00ae: in-vitro mechanism paper in Scientific Reports (2026), an open-label SGS clinical study and a 34-subject, double-blind, placebo-controlled, split-face clinical study conducted by Intertek (to be published).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dermatide.net\/ko\/\uacfc\ud559\uc801-\uc99d\uac70\/\" \/>\n<meta property=\"og:site_name\" content=\"Dermatide\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-25T02:54:20+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\uc608\uc0c1 \ub418\ub294 \ud310\ub3c5 \uc2dc\uac04\" \/>\n\t<meta name=\"twitter:data1\" content=\"6\ubd84\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/dermatide.net\\\/science-evidence\\\/\",\"url\":\"https:\\\/\\\/dermatide.net\\\/science-evidence\\\/\",\"name\":\"Science &amp; Evidence - Dermatide\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/dermatide.net\\\/#website\"},\"datePublished\":\"2025-10-09T07:25:08+00:00\",\"dateModified\":\"2026-10-25T02:54:20+00:00\",\"description\":\"The science behind AKNETIDE\u00ae: in-vitro mechanism paper in Scientific Reports (2026), an open-label SGS clinical study and a 34-subject, double-blind, placebo-controlled, split-face clinical study conducted by Intertek (to be published).\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/dermatide.net\\\/science-evidence\\\/#breadcrumb\"},\"inLanguage\":\"ko-KR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/dermatide.net\\\/science-evidence\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/dermatide.net\\\/science-evidence\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/dermatide.net\\\/en-us\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Science &amp; Evidence\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/dermatide.net\\\/#website\",\"url\":\"https:\\\/\\\/dermatide.net\\\/\",\"name\":\"Dermatide\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/dermatide.net\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/dermatide.net\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ko-KR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/dermatide.net\\\/#organization\",\"name\":\"Dermatide\",\"url\":\"https:\\\/\\\/dermatide.net\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ko-KR\",\"@id\":\"https:\\\/\\\/dermatide.net\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/dermatide.net\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/dermatide.png\",\"contentUrl\":\"https:\\\/\\\/dermatide.net\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/dermatide.png\",\"width\":406,\"height\":105,\"caption\":\"Dermatide\"},\"image\":{\"@id\":\"https:\\\/\\\/dermatide.net\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\uacfc\ud559 \ubc0f \uc99d\uac70 - Dermatide","description":"AKNETIDE\u00ae\uc758 \uacfc\ud559\uc801 \ubc30\uacbd: Scientific Reports(2026)\uc758 in-vitro \uae30\uc804 \ub17c\ubb38, \uc624\ud508 \ub77c\ubca8 SGS \uc784\uc0c1 \uc5f0\uad6c \ubc0f Intertek\uc774 \uc218\ud589\ud55c \ud53c\ud5d8\uc790 34\uba85 \uaddc\ubaa8\uc758 \uc774\uc911\ub9f9\uac80, \uc704\uc57d \ub300\uc870, \ubd84\ud560 \uc548\uba74(split-face) \uc784\uc0c1 \uc5f0\uad6c(\ubc1c\ud45c \uc608\uc815).","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dermatide.net\/ko\/\uacfc\ud559\uc801-\uc99d\uac70\/","og_locale":"ko_KR","og_type":"article","og_title":"Science &amp; Evidence - Dermatide","og_description":"The science behind AKNETIDE\u00ae: in-vitro mechanism paper in Scientific Reports (2026), an open-label SGS clinical study and a 34-subject, double-blind, placebo-controlled, split-face clinical study conducted by Intertek (to be published).","og_url":"https:\/\/dermatide.net\/ko\/\uacfc\ud559\uc801-\uc99d\uac70\/","og_site_name":"Dermatide","article_modified_time":"2026-10-25T02:54:20+00:00","twitter_card":"summary_large_image","twitter_misc":{"\uc608\uc0c1 \ub418\ub294 \ud310\ub3c5 \uc2dc\uac04":"6\ubd84"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/dermatide.net\/science-evidence\/","url":"https:\/\/dermatide.net\/science-evidence\/","name":"\uacfc\ud559 \ubc0f \uc99d\uac70 - Dermatide","isPartOf":{"@id":"https:\/\/dermatide.net\/#website"},"datePublished":"2025-10-09T07:25:08+00:00","dateModified":"2026-10-25T02:54:20+00:00","description":"AKNETIDE\u00ae\uc758 \uacfc\ud559\uc801 \ubc30\uacbd: Scientific Reports(2026)\uc758 in-vitro \uae30\uc804 \ub17c\ubb38, \uc624\ud508 \ub77c\ubca8 SGS \uc784\uc0c1 \uc5f0\uad6c \ubc0f Intertek\uc774 \uc218\ud589\ud55c \ud53c\ud5d8\uc790 34\uba85 \uaddc\ubaa8\uc758 \uc774\uc911\ub9f9\uac80, \uc704\uc57d \ub300\uc870, \ubd84\ud560 \uc548\uba74(split-face) \uc784\uc0c1 \uc5f0\uad6c(\ubc1c\ud45c \uc608\uc815).","breadcrumb":{"@id":"https:\/\/dermatide.net\/science-evidence\/#breadcrumb"},"inLanguage":"ko-KR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dermatide.net\/science-evidence\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/dermatide.net\/science-evidence\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dermatide.net\/en-us\/"},{"@type":"ListItem","position":2,"name":"Science &amp; Evidence"}]},{"@type":"WebSite","@id":"https:\/\/dermatide.net\/#website","url":"https:\/\/dermatide.net\/","name":"Dermatide","description":"","publisher":{"@id":"https:\/\/dermatide.net\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dermatide.net\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ko-KR"},{"@type":"Organization","@id":"https:\/\/dermatide.net\/#organization","name":"Dermatide","url":"https:\/\/dermatide.net\/","logo":{"@type":"ImageObject","inLanguage":"ko-KR","@id":"https:\/\/dermatide.net\/#\/schema\/logo\/image\/","url":"https:\/\/dermatide.net\/wp-content\/uploads\/2025\/09\/dermatide.png","contentUrl":"https:\/\/dermatide.net\/wp-content\/uploads\/2025\/09\/dermatide.png","width":406,"height":105,"caption":"Dermatide"},"image":{"@id":"https:\/\/dermatide.net\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/dermatide.net\/ko\/wp-json\/wp\/v2\/pages\/540","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dermatide.net\/ko\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dermatide.net\/ko\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dermatide.net\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dermatide.net\/ko\/wp-json\/wp\/v2\/comments?post=540"}],"version-history":[{"count":32,"href":"https:\/\/dermatide.net\/ko\/wp-json\/wp\/v2\/pages\/540\/revisions"}],"predecessor-version":[{"id":2441,"href":"https:\/\/dermatide.net\/ko\/wp-json\/wp\/v2\/pages\/540\/revisions\/2441"}],"wp:attachment":[{"href":"https:\/\/dermatide.net\/ko\/wp-json\/wp\/v2\/media?parent=540"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}