{"id":540,"date":"2025-10-09T07:25:08","date_gmt":"2025-10-09T07:25:08","guid":{"rendered":"https:\/\/dermatide.net\/?page_id=540"},"modified":"2026-04-06T13:11:48","modified_gmt":"2026-04-06T13:11:48","slug":"science-evidence","status":"publish","type":"page","link":"https:\/\/dermatide.net\/en\/science-evidence\/","title":{"rendered":"Science & Evidence"},"content":{"rendered":"\t\t
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Tracing the Scientific Breakthroughs Behind<\/span> AKNETIDE\u00ae<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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AKNETIDE\u00ae <\/sup>R&D has been grounded over a decade of research from molecular discovery to clinical validation. Below is a snapshot of key scientific and regulatory milestones that demonstrate its journey from lab bench to real-world acne care efficacy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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2014<\/h4>

Inception of AMP<\/h2> <\/div>\n

Inception of antimicrobial peptide discovery from nature and lab development<\/p><\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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2019<\/h4>

Granted the world first ever AMP additive for animal nutrition and health<\/h2> <\/div>\n

Granted the world first-ever antimicrobial peptide zootechnical additive for animal nutrition<\/p><\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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2023<\/h4>

The cyclopeptide was discovered<\/h2> <\/div>\n

AKNETIDE\u00ae<\/sup>, a novel antimicrobial cyclopeptide\u00a0with potent inhibition against C. acne<\/em> and S. aureus<\/em>,\u00a0was discovered<\/p><\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t

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2024<\/h4>

First clinical study by SGS<\/h2> <\/div>\n

The first-ever clinical study, with SGS Cosmetic Lab, was completed and demonstrated the significant efficacy of sensible acne level alleviation<\/p><\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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2025<\/h4>

Multi-MOAs established and a strict hospital clinical study completed<\/h2> <\/div>\n

Mechanism Elucidation<\/b><\/strong>: <\/b><\/strong>Multi-MOAs were established\u00a0and proven\u00a0by a leading cosmetic research institute<\/p>

A double-blinded placebo-controlled Clinical Study in a world-famous\u00a0Dermatology Hospital was conducted.<\/p><\/div> <\/div>\n <\/div>\n\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Scientifically proven and Dermatologist Endorsed evidences behind AKNETIDE\u00ae <\/sup><\/span> <\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Backed by 10+ years of rigorous consistent research of antimicrobial bioactive peptides, and recently validated by leading independent biochemical laboratories\u00a0and top-tier dermatology hospital, AKNETIDE\u00ae\u00a0harvested myriads of evidences, either of mechanism or of clinical studies, enables it deserving\u00a0a\u00a0worldwide breakthrough anti acne cosmetic ingredient designed for EFFICACY\u00a0without bragging.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t

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Double-Blind Hospital Study<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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A dermatology hospital clinical study. A 7-day double-blinded placebo-controlled clinical study demonstrated the prototype formula embedded ANKENTIDE\u00ae <\/sup>efficacious in alleviating acne and improving skin conditions of volunteers<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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SGS Clinical Study<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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AKNETIDE\u00ae <\/sup>embedded prototype formula demonstrated potent efficacy in significantly alleviating volunteers’ acne conditions from black heads to papules in 7 days.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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In-vitro Safety Studies<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Skin irritation, phototoxicity, eye irritation, sensitization\u00a0to skin were all tested NEGATIVE; \u00a0HaCaT MTT Toxicity data was given.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Published Studies and Patents<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Scientific publications documenting AKNETIDE\u00ae<\/sup>‘s clinical findings and mechanism of action are currently in preparation for peer-reviewed journal submission.<\/p>

Pre-publication data is available to qualified cosmetic manufacturers and researchers under NDA.\u00a0<\/p>

Contact info@dermatide.net to request access.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Frequently Asked Questions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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<\/path><\/svg><\/span><\/path><\/svg><\/span>What clinical evidence supports AKNETIDE\u00ae?<\/span><\/path><\/svg><\/div>

AKNETIDE\u00ae <\/sup>has been evaluated in a 7-day double-blind clinical study conducted through SGS, a globally recognised testing institution. Results showed an 88.7% reduction in blackheads, 51.0% reduction in papules, and 16.3% overall reduction in total acne lesions. A hospital-based dermatology trial was completed in 2025 to further validate multi-mechanism performance.<\/p><\/div>\n <\/div>

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<\/path><\/svg><\/span><\/path><\/svg><\/span>Is AKNETIDE\u00ae<\/sup><\/button> safe for sensitive skin?<\/span><\/path><\/svg><\/div>

Yes. AKNETIDE\u00ae <\/sup>has undergone in-vitro safety assessments for irritation, phototoxicity, and sensitisation, all of which confirmed a favourable safety profile. It has received dermatologist-tested designation and is COSMOS-approved as a natural raw material \u2014 suitable for use in cosmetic formulations targeting sensitive and reactive skin types.<\/p><\/div>\n <\/div>

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<\/path><\/svg><\/span><\/path><\/svg><\/span>What is an antimicrobial cyclopeptide and how is it different from other anti-acne actives?<\/span><\/path><\/svg><\/div>

An antimicrobial cyclopeptide is a ring-structured peptide that mimics the body’s host defence mechanisms to selectively inhibit pathogenic bacteria. Unlike antibiotics or chemical actives, cyclopeptides work by disrupting bacterial membrane integrity without promoting antibiotic resistance. AKNETIDE\u00ae <\/sup>is derived from a natural cyclopeptide scaffold and is the first of its class developed for cosmetic acne applications.<\/p><\/div>\n <\/div>

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<\/path><\/svg><\/span><\/path><\/svg><\/span>Has AKNETIDE\u00ae<\/sup><\/button> been published in peer-reviewed journals?<\/span><\/path><\/svg><\/div>

Publication of AKNETIDE\u00ae <\/sup>‘s clinical and mechanistic data in peer-reviewed journals is in progress. The foundational antimicrobial peptide research behind AKNETIDE\u00ae <\/sup>spans from 2014, with the first regulatory approval of a related AMP zootechnical additive in 2019. Scientific publications are expected to be available shortly \u2014 please contact info@dermatide.net for pre-publication data on file.<\/p><\/div>\n <\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Tracing the Scientific Breakthroughs Behind AKNETIDE\u00ae AKNETIDE\u00ae R&D has been grounded over a decade of research from molecular discovery to clinical validation. Below is a snapshot of key scientific and regulatory milestones that demonstrate its journey from lab bench to real-world acne care efficacy. 2014 Inception of AMP Inception of antimicrobial peptide discovery from nature […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-540","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nScience & Evidence - Dermatide<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dermatide.net\/en\/science-evidence\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science & Evidence - Dermatide\" \/>\n<meta property=\"og:description\" content=\"Tracing the Scientific Breakthroughs Behind AKNETIDE\u00ae AKNETIDE\u00ae R&D has been grounded over a decade of research from molecular discovery to clinical validation. 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